Biochemistry and pathobiochemistry deals mainly with biochemical and molecular biological problems of biomacromolecules, i.e. proteins and enzymes, lipids and nucleic acids, as well as their structural and other important low-molecular substances in nutrient systems.
The aim of the study also clarifies their mutual substance metabolism and their role in the regulation of life processes such as hormones, neurotransmitters, growth factors, receptors, antibodies, signal molecules etc. A very important field is also research into biological membranes, membrane transporters, subcellular components, energy transformations, extracellular matrix and the role of the second messengers in cell regulation. The research focused on the role of free radicals in terms of their action as mutagens, on the research of other toxic agents for nucleic acids and biomembranes and on the research of carcinogenesis and atherogenesis. The methodological field requires knowledge of fundamental techniques and separation and functional characterization of biomacromolecules as well as low-molecular biochemical components of cells and body fluids, or molecular biology techniques, or cell and tissue culture cultivation.
This study program focuses on monitoring and determination of substrates and products of normal and pathological metabolism, hereditary and acquired metabolic disorders, and on the maintenance of a constant internal environment of the organism. Biochemistry and pathobiochemistry form smooth transitions to molecular biology as well as to a number of basic and clinical disciplines, especially for clinical biochemistry, with which it largely coincides.
The study program is carried out in collaboration with the Institute of Molecular Genetics, the Institute of Physiology and the Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic.
Description of verification and evaluation criteria
Duly completed master’s study program, i.e. submission of a certified copy of the university diploma or the nostrification of university education, by 30 September 2019.
Submission of the application form including all relevant enclosures, i.e. CV, professional reference, payment receipt of the admission fee by 30 April 2019
Submission of the dissertation project by 30 April 2019
Successful completion of the exam, which is based on appropriate knowledge in the scientific field chosen.
Entrance exams take the form of an interview on the topic of the Ph.D. Thesis, demonstrating the technical skills of the applicant for a doctoral study program and the ability to work with specialized foreign literature. The project is assessed by the expert committee.
Conditions for admission
Admission to Doctoral studies is conditioned by successful completion of a Master's study program.
Confirmation date (of entrance exam)
from: 01.06.2019 Until: 30.06.2019
Alternative date (of entrance exam):
from: 01.07.2019 Until: 15.07.2019
Recommended literature, sample questions
Readings are recommended by individual potential supervisors and are based on professional issues of the potential dissertation and the chosen particular discipline. In particular, monographs and respected IF magazines. Suggested literature and resources can be viewed within the profiles of the specific supervisors.
Further information on the website of the Academy of Sciences of the Czech Republic: http://dspb.avcr.cz
Doctoral (Ph.D.) study program Biochemistry and pathobiochemistry deals with the molecular-biological characterization of biomacromolecules and their building blocks in health and disease, elucidation of their mutual metabolism, role in the regulation of physiological processes and their disorders. An important area is also the investigation of biological membranes, subcellular compartments (organelles), energy turnover, extracellular matrix and the role of second messengers in cell regulations. The program is also concerned with the role of free radicals in relation to cancerogenesis and atherogenesis. It is closely linked to molecular biology and genetics and to many basic and clinical branches of biomedicine, esp. to clinical biochemistry. The standard length of study is four (4) years.